Chronodisruption and Lung Fibrosis: The Role of Circadian Rhythm Disturbances in the Onset and Progression of Idiopathic Pulmonary Fibrosis

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by irreversible scarring and declining lung function. The circadian clock governs a wide array of physiological processes, including inflammation, immune regulation, cellular repair, and metabolism, all of which are implicated in fibrotic lung pathology. This review synthesizes current insights into the molecular crosstalk between circadian rhythm regulators and profibrotic signaling pathways in IPF. We also explore how lifestyle, environmental cues, and shift work may influence lung fibrosis risk through clock gene dysregulation. Furthermore, we examine the potential for chronotherapy and circadian-aligned pharmacological interventions in improving outcomes for IPF patients. Understanding the temporal architecture of fibrosis could offer novel therapeutic targets and a paradigm shift in IPF management.